Downstream processing from melt granulation towards tablets: In-depth analysis of a continuous twin-screw melt granulation process using polymeric binders

Continuous Granulation with a Twin-Screw Extruder

Twin Screw Granulation – A Literature Review

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Formulation and Evaluation of Diclofenac Sodium Sustained Release Tablets Using Melt Granulation Technique

Hydrophilic polymers alone are not quite efficient in controlling the release of highly water soluble drugs. Hydrophobic Polymer and pore forming agent have been extensively investigated for sustaining the release of drug. They provide several advantages include good stability at varying pH ranges and effectively retards the water soluble drug. In the present study it was a novel approach where...

Improvement in Physicochemical Properties of Indomethacin by Melt Granulation Technique

Indomethacin (IM), most widely used non-steroidal anti-inflammatory drug widely used in developing countries, is classified in Class II in the Biopharmaceutics Classification Systems; this means that IM has very low water solubility and high permeability, thus the dissolution is the absorption rate-limiting factor. The aim of this work was to evaluate the suitability of melt granulation techniq...

Improved Dissolution and Micromeritic Properties of Ibuprofen by Continuous Twin Screw Hot Melt Granulation Using Kolliphor P 188 Micro as Meltable Binder